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김성원 우수논문 사례 2017.12.15
작 성 자  : 관리자 HIT  : 2266
첨부파일  : Printing three-dimensional tissue analogues.pdf
Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

Falguni Pati1,*, Jinah Jang2,3,*, Dong-Heon Ha1, Sung Won Kim4,5, Jong-Won Rhie6, Jin-Hyung Shim7,Deok-Ho Kim3,8,9 & Dong-Woo Cho1

1 Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam ro, Nam-gu, Pohang, Kyungbuk 790-784,
South Korea. 2 Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), 77 Cheongam ro, Nam-gu,
Pohang, Kyungbuk 790-784, South Korea. 3 Department of Bioengineering, University of Washington, Seattle, Waltham 98195, USA. 4 Department of
Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-710, South Korea.
5 Department of Biomedical Science, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, South Korea.
6 Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, South Korea.
7 Department of Mechanical Engineering, Korea Polytechnic University, 2121 Jeongwang-dong, Siheungsi, Gyeonggi-do 429-793, South Korea. 8 Center for
Cardiovascular Biology, University of Washington, Seattle, Waltham 98109, USA. 9 Institute for Stem Cell and Regenerative Medicine, University of
Washington, Seattle, WA 98109, USA.

ABSTRACT

The ability to print and pattern all the components that make up a tissue (cells and matrix materials) in three dimensions to generate structures similar to tissues is an exciting prospect
of bioprinting. However, the majority of the matrix materials used so far for bioprinting cannot represent the complexity of natural extracellular matrix (ECM) and thus are unable to
reconstitute the intrinsic cellular morphologies and fuNctions. Here, we develop a method for the bioprinting of cell-laden constructs with novel decellularized extracellular matrix (dECM)
bioink capable of providing an optimized microenvironment conducive to the growth of three-dimensional structured tissue. We show the versatility and flexibility of the developed bioprinting process using tissue-specific dECM bioinks, including adipose, cartilage and
heart tissues, capable of providing crucial cues for cells engraftment, survival and long-term fuNction. We achieve high cell viability and fuNctionality of the printed dECM
structures using our bioprinting method.
 
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